Raguin G
Service de Médecine Interne-Maladies Infectieuses, Hôpital de la Croix-Saint-Simon, Paris.
Ann Med Interne (Paris). 1997;148(3):218-25.
The immunocompromised host is an individual whose defense mechanisms against infectious agents are altered in such a significant way that he is abnormally susceptible to infections agents in general and bacterial "opportunists" in particular. The type of infection and etiologic agents vary with the nature and the severity of the immune defect. The goal of prophylactic treatments is to prevent the occurrence or recurrence of infections, and so, to reduce the infectious morbidity and mortality when the nature of severity of immunosuppression make these complications probable. Beside specific measures, which are detailed in this article, the strict application of the so-called universal precautions, particularly handwashing, remain at the basis of the prevention of bacterial infections in the immunocompromised host.
免疫功能低下宿主是指其针对感染因子的防御机制发生显著改变,以至于总体上对感染因子异常易感,尤其是对细菌“机会致病菌”易感的个体。感染的类型和病原体因免疫缺陷的性质和严重程度而异。预防性治疗的目的是预防感染的发生或复发,从而在免疫抑制的性质或严重程度使这些并发症有可能发生时,降低感染的发病率和死亡率。除了本文详细介绍的具体措施外,严格应用所谓的通用预防措施,尤其是洗手,仍然是预防免疫功能低下宿主细菌感染的基础。