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所谓“血管内细支气管肺泡瘤”的组织发生

Histogenesis of the so-called "intravascular bronchioloalveolar tumour".

作者信息

Corrin B, Manners B, Millard M, Weaver L

出版信息

J Pathol. 1979 Jul;128(3):163-7. doi: 10.1002/path.1711280308.

DOI:10.1002/path.1711280308
PMID:92557
Abstract

Three cases of Dial and Liebow's intravascular bronchioloalveolar tumour are described, with emphasis on ultrastructure and histogenesis. The tumour cells are quite different from adjacent reactive alveolar cells and electron microscopy does not support the suggested alveolar cell origin. The tumour cells contain abundant microfilaments, moderate amounts of rough endoplasmic reticulum and varying numbers of Weibel-Palade bodies. With features of smooth muscle, myofibroblast and endothelial cell differentiation, a vascular origin from precursor mesenchymal cells such as the vasoformative reserve cells is suggested.

摘要

本文描述了3例戴尔和利博的血管内细支气管肺泡肿瘤,重点介绍了其超微结构和组织发生。肿瘤细胞与相邻的反应性肺泡细胞有很大不同,电子显微镜检查不支持所提出的肺泡细胞起源。肿瘤细胞含有丰富的微丝、适量的粗面内质网和数量不等的魏贝尔-帕拉德小体。鉴于其具有平滑肌、肌成纤维细胞和内皮细胞分化的特征,提示其起源于血管形成储备细胞等间充质前体细胞。

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