Sequence-specific 1H, 13C and 15N assignment of the TMP-resistant dihydrofolate reductase mutant DHFR(F98Y) in the ternary complex with TMP and NADPH.
作者信息
Altmann S, Labhardt A M, Senn H, Wüthrich K
机构信息
Pharma Division, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
出版信息
J Biomol NMR. 1997 Jun;9(4):445-6. doi: 10.1023/a:1018315131994.
PMID:9255948
Abstract
摘要
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Sequence-specific 1H, 13C and 15N assignment of the TMP-resistant dihydrofolate reductase mutant DHFR(F98Y) in the ternary complex with TMP and NADPH.与甲氧苄啶（TMP）和烟酰胺腺嘌呤二核苷酸磷酸（NADPH）形成三元复合物的耐甲氧苄啶二氢叶酸还原酶突变体DHFR（F98Y）的序列特异性氢-1（1H）、碳-13（13C）和氮-15（15N）归属
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本文引用的文献
1
The program XEASY for computer-supported NMR spectral analysis of biological macromolecules.用于生物大分子的计算机支持的 NMR 光谱分析的 XEASY 程序。
J Biomol NMR. 1995 Jul;6(1):1-10. doi: 10.1007/BF00417486.
2
Three-dimensional (1)H-TOCSY-relayed ct-[(13)C, (1)H]-HMQC for aromatic spin system identification in uniformly (13)C-labeled proteins.三维 (1)H-TOCSY 相关 ct-[(13)C, (1)H]-HMQC 用于均匀 (13)C 标记蛋白质中芳香族自旋系统的鉴定。
J Biomol NMR. 1996 Mar;7(2):99-106. doi: 10.1007/BF00203820.
3
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J Med Pharm Chem. 1962 Nov;5:1103-23. doi: 10.1021/jm01241a004.
4
Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins.相敏二维相关光谱法（COSY）在蛋白质中¹H-¹H自旋-自旋耦合常数测量中的应用。
Biochem Biophys Res Commun. 1983 Jun 29;113(3):967-74. doi: 10.1016/0006-291x(83)91093-8.
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