Tatsumi K, Amino N
Department of Laboratory Medicine, Osaka University Medical School, Suita.
Rinsho Byori. 1997 Jul;45(7):656-9.
Pit-1/GHF-1 is a pituitary specific POU-domain DNA binding factor, which transactivates the growth hormone (GH), prolactin (PRL), thyrotropin beta subunit (TSH beta) genes, and PIT1 gene itself. It is indispensable for the differentiation and the proliferation of the cells producing GH, and PRL. Loss of the PIT1 gene function (PIT1 abnormality) results in combined deficiency of GH, PRL, and TSH. PIT1 abnormality serves as a model of transcription factor abnormalities.
Pit-1/GHF-1是一种垂体特异性POU结构域DNA结合因子，它可反式激活生长激素（GH）、催乳素（PRL）、促甲状腺激素β亚基（TSHβ）基因以及PIT1基因本身。它对于产生GH和PRL的细胞的分化和增殖是不可或缺的。PIT1基因功能丧失（PIT1异常）会导致GH、PRL和TSH联合缺乏。PIT1异常是转录因子异常的一种模型。
