呼肠孤病毒的中和作用：负责中和抗原的基因。
Neutralization of reovirus: the gene responsible for the neutralization antigen.
作者信息
Weiner H L, Fields B N
出版信息
J Exp Med. 1977 Nov 1;146(5):1305-10. doi: 10.1084/jem.146.5.1305.
Abstract
The S1 genome segment of reovirus is linked to type specificity as determined by neutralization antibody. This gene segment codes for a minor outer capsid polypeptide (sigma1). Therefore, sigma1 is the peptide responsible for induction of neutralization antibody and confers type specificity. This biologic property of reovirus was defined using hybrid recombinants clones between reovirus types 1 and 3 and 2 and 3.
摘要
呼肠孤病毒的S1基因组片段与中和抗体所确定的型特异性相关。该基因片段编码一种次要的外衣壳多肽（σ1）。因此，σ1是负责诱导中和抗体并赋予型特异性的肽段。呼肠孤病毒的这种生物学特性是通过呼肠孤病毒1型与3型以及2型与3型之间的杂交重组克隆来确定的。
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