呼肠孤病毒毒力的分子基础。M2基因的作用。
Molecular basis of reovirus virulence. Role of the M2 gene.
作者信息
Rubin D H, Fields B N
出版信息
J Exp Med. 1980 Oct 1;152(4):853-68. doi: 10.1084/jem.152.4.853.
Abstract
The mammalian reoviruses (serotype 1, strain Lang and serotype 3, strain Dearing) differ in their sensitivity to digestion by chymotrypsin. We have found that the M2 double-stranded RNA (dsRNA) genome segment (encoding the micro1C outer capsid polypeptide) is responsible for this property. In addition to determining response to protease treatement in vitro, we have found that the M2 genome segment also determines the ability of these two viruses successfully to initiate local and systemic infection in newborn mice after peroral inoculation. Thus the M2 dsRNA segment defines a new virulence gene of the mammalian reoviruses.
摘要
哺乳动物呼肠孤病毒（血清1型，Lang株和血清3型，Dearing株）对胰凝乳蛋白酶消化的敏感性不同。我们发现M2双链RNA（dsRNA）基因组片段（编码micro1C外衣壳多肽）决定了这一特性。除了决定体外对蛋白酶处理的反应外，我们还发现M2基因组片段也决定了这两种病毒经口接种后在新生小鼠中成功引发局部和全身感染的能力。因此，M2 dsRNA片段定义了哺乳动物呼肠孤病毒的一个新的毒力基因。
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