Marmont A M, van Lint M T, Gualandi F, Bacigalupo A
Division of Haematology and Bone Marrow Transplantation Centre, San Martino's Hospital, Genova, Italy.
Lupus. 1997;6(6):545-8. doi: 10.1177/096120339700600613.
A 46 year woman with severe long-lasting SLE received an autologous bone marrow transplantation utilising CD34+ haematopoietic progenitors following a 3log T-lymphocyte depletion. The immunosuppressive regimen (conditioning) consisted of 15mg/kg Thiotepa followed by 100 mg/kg of cyclophosphamide over 2d. Granulocytic recovery was aided by G-CSF. The post-transplant course was uneventful, and a good clinical and immunologic remission (ANA negativisation) was achieved. This is the first case of SLE having received an autologous progenitor cell transplant for the autoimmune disease by itself, unaccompanied by a haematologic condition requiring transplantation. The potential, advantages and limits of this procedure, which are currently being explored worldwide, are briefly discussed.
一名46岁患有严重长期系统性红斑狼疮（SLE）的女性，在进行3对数T淋巴细胞清除后，接受了利用CD34 +造血祖细胞的自体骨髓移植。免疫抑制方案（预处理）包括15mg/kg的噻替哌，随后在2天内给予100mg/kg的环磷酰胺。粒细胞集落刺激因子（G-CSF）辅助粒细胞恢复。移植后的过程平稳，实现了良好的临床和免疫缓解（抗核抗体转阴）。这是首例自身免疫性疾病SLE未经需要移植的血液系统疾病而单独接受自体祖细胞移植的病例。本文简要讨论了目前正在全球范围内探索的该治疗方法的潜力、优势和局限性。
