Czeizel A E, Hirschberg J
Department of Human Genetics and Teratology, National Institute of Public Health, Budapest, Hungary.
Folia Phoniatr Logop. 1997;49(3-4):111-6. doi: 10.1159/000266446.
The occurrences (birth prevalences) of different types of isolated and multiple orofacial clefts are known in Hungary. The empiric risk figures in the first-degree relatives of probands with cleft lip +/- cleft palate, cleft palate, Robin sequence and multiple congenital abnormalities including orofacial clefts as component defects were also determined. Finally the recent controversial data concerning the primary prevention of isolated orofacial clefts by periconceptional folic acid-containing multivitamins are summarized.
匈牙利已知不同类型的孤立性和多发性口面部裂隙的发生率（出生患病率）。还确定了唇裂±腭裂、腭裂、罗宾序列以及包括口面部裂隙作为组成缺陷的多发性先天性异常的先证者一级亲属中的经验风险数字。最后总结了近期关于在受孕前服用含叶酸多种维生素对孤立性口面部裂隙进行一级预防的有争议的数据。
