Faraone S V, Biederman J, Wozniak J, Mundy E, Mennin D, O'Donnell D
Pediatric Psychopharmacology Unit, Child Psychiatry Service, Massachusetts General Hospital, Boston 02114, USA.
J Am Acad Child Adolesc Psychiatry. 1997 Aug;36(8):1046-55. doi: 10.1097/00004583-199708000-00012.
To compare the characteristics and correlates of mania in referred adolescents and to determine whether attention-deficit hyperactivity disorder (ADHD) is a marker of very early onset mania.
From 637 consecutive admissions, 68 children (< or = 12 years) and 42 adolescents (> 13 years) who satisfied criteria for mania were recruited. These were compared with the 527 nonmanic referrals and 100 normal controls.
With the exception of comorbidity with ADHD, there were more similarities than differences between the children and adolescents with mania in course and correlates. There was an inverse relationship between the rates of comorbid ADHD and age of onset of mania: higher in manic children intermediate in adolescents with childhood-onset mania, and lower in adolescents with adolescent-onset mania.
ADHD is more common in childhood-onset compared with adolescent-onset cases of bipolar disorder, suggesting that in some cases, ADHD may signal a very early onset of bipolar disorder. Clinical similarities between the child- and adolescent-onset cases provide evidence for the clinical validity of childhood-onset mania.
比较转诊青少年躁狂症的特征及相关因素，并确定注意力缺陷多动障碍（ADHD）是否为极早发性躁狂症的一个标志。
从637例连续入院患者中，招募了68名儿童（≤12岁）和42名青少年（>13岁），他们符合躁狂症标准。将这些患者与527名非躁狂转诊患者及100名正常对照进行比较。
除了与ADHD共病外，患躁狂症的儿童和青少年在病程及相关因素方面的相似之处多于差异。共病ADHD的发生率与躁狂症发病年龄呈负相关：在患躁狂症的儿童中较高，在童年期起病的青少年中居中，在青少年期起病的青少年中较低。
与青少年期起病的双相情感障碍病例相比，ADHD在童年期起病的病例中更为常见，这表明在某些情况下，ADHD可能预示着双相情感障碍的极早发病。儿童期起病和青少年期起病病例之间的临床相似性为儿童期起病躁狂症的临床有效性提供了证据。
