莫洛尼鼠白血病病毒细胞内前体多聚蛋白的特性分析
Characterization of intracellular precursor polyproteins of Moloney murine leukemia virus.
作者信息
Ng V L, Wood T G, Lyons D D, Arlinghaus R B
出版信息
J Virol. 1979 Dec;32(3):1051-6. doi: 10.1128/JVI.32.3.1051-1056.1979.
Intracellular Moloney murine leukemia viral precursor polyproteins were compared with mature viral proteins by immunoprecipitation and tryptic peptide mapping experiments. The results were consistent with precursor roles for Pr65gag, Pr200gag-pol, Pr135pol, and gPr83env. The glycosylated gag gene product gPr85gag, although containing sequences characteristic of all four core proteins plus additional sequences not found in Pr65gag, lacked a major tyrosine-containing p30 tryptic peptide, suggesting that gPr85gag is not processed to p30.
通过免疫沉淀和胰蛋白酶肽图谱实验，对细胞内莫洛尼氏鼠白血病病毒前体多蛋白与成熟病毒蛋白进行了比较。结果与Pr65gag、Pr200gag-pol、Pr135pol和gPr83env的前体作用一致。糖基化的gag基因产物gPr85gag，虽然包含所有四种核心蛋白的特征序列以及Pr65gag中未发现的其他序列，但缺乏一个主要的含酪氨酸的p30胰蛋白酶肽，这表明gPr85gag不会加工成p30。
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