Bisht D, Misra V, Gupta S C, Tewarson S L, Bahuguna S
Department Pathology, M.L.N. Medical College, Allahabad.
Indian J Pathol Microbiol. 1997 Apr;40(2):147-51.
Alkaline phosphatase have been demonstrated histochemically in the cytoplasm of neutrophils. Altered LAP activity has been observed in a number of conditions. Increased values are found in various inflammatory lesions where as in different malignancies LAP falls. Our study was aimed to see the alteration in LAP activity in case of squamous cell carcinoma. The study was carried out in peripheral blood smears of 185 cases (110 cases of squamous cell carcinoma and 75 of normal persons). After histochemical staining, LAP scoring was done. LAP score in Squamous cell carcinoma (mean +/- SD = 57.41 +/- 16.9). No significant difference in LAP score was found according to the site and grade of carcinoma, and in relation to metastasis. 43 cases were followed up after variable periods of treatment. LAP score was found to be significantly raised following treatment, (mean +/- SD = 21.14 +/- 5.94, p < 0.001). It is concluded that LAP scoring might be used as a cheap and simple technique to diagnose occult malignancies and to assess the response to therapy.
碱性磷酸酶已通过组织化学方法在中性粒细胞的细胞质中得到证实。在许多情况下都观察到了白细胞碱性磷酸酶（LAP）活性的改变。在各种炎症性病变中发现其值升高，而在不同的恶性肿瘤中LAP值下降。我们的研究旨在观察鳞状细胞癌患者LAP活性的变化。该研究在185例患者的外周血涂片上进行（110例鳞状细胞癌患者和75例正常人）。经过组织化学染色后，进行LAP评分。鳞状细胞癌的LAP评分（平均值±标准差=57.41±16.9）。根据癌的部位、分级以及有无转移，LAP评分未发现显著差异。43例患者在经过不同疗程的治疗后进行了随访。发现治疗后LAP评分显著升高（平均值±标准差=21.14±5.94，p<0.001）。结论是，LAP评分可作为一种廉价且简单的技术用于诊断隐匿性恶性肿瘤以及评估治疗反应。
