Schmanke T, Barth T M
Mental Retardation Research Center, University of California at Los Angeles, 90024, USA.
J Neurotrauma. 1997 Jul;14(7):459-68. doi: 10.1089/neu.1997.14.459.
This study investigated the relative contribution of amphetamine administration and task-specific practice during the period of drug action to recovery of forelimb-placing ability after unilateral electrolytic lesions of the sensorimotor cortex (SMC) in rats. Subjects were divided into groups receiving amphetamine plus postinjection forelimb-placing practice, amphetamine only, saline plus postinjection forelimb-placing practice, or saline only. The results revealed that groups of subjects receiving either amphetamine, postinjection practice, or a combination of these treatments exhibited the greatest enhancement of rates of vibrissae-evoked forelimb-placing recovery. These data suggest that these treatments can have an enduring beneficial effect on vibrissae-evoked forelimb-placing recovery without any immediate restorative effect on forelimb-placing ability. The recovery patterns and experimental evidence (see Feeney and Sutton, 1988; Chaouloff, 1989) suggest that the beneficial effect of the two therapies may be mediated by catecholamine release.
本研究调查了在药物作用期间给予苯丙胺和特定任务练习对大鼠单侧感觉运动皮层（SMC）电解损伤后前肢放置能力恢复的相对贡献。将实验对象分为四组，分别给予苯丙胺加注射后前肢放置练习、仅给予苯丙胺、生理盐水加注射后前肢放置练习或仅给予生理盐水。结果显示，接受苯丙胺、注射后练习或这两种治疗组合的实验对象组，其触须诱发的前肢放置恢复率提高最为显著。这些数据表明，这些治疗方法可对触须诱发的前肢放置恢复产生持久的有益影响，而对前肢放置能力没有任何即时恢复作用。恢复模式和实验证据（见Feeney和Sutton，1988；Chaouloff，1989）表明，这两种治疗方法的有益作用可能是由儿茶酚胺释放介导的。
