van den Broek M F, Spörri R, Even C, Plagemann P G, Hänseler E, Hengartner H, Zinkernagel R M
Institute of Experimental Immunology, Department of Pathology, University of Zurich, Switzerland.
J Immunol. 1997 Aug 15;159(4):1585-8.
Viruses have developed various strategies to coexist with vertebrate hosts. Lactate dehydrogenase-elevating virus (LDV) is a highly cytopathic virus exhibiting an extraordinary rate of replication; LDV nevertheless establishes a persistent infection without harming the host. The cytotoxic and helper T cell responses to LDV were monitored in mice with different genetic backgrounds. LDV-specific cytotoxic and helper T cells were found in all strains tested. These responses persisted for at least up to 250 days despite high levels of LDV in the blood. Thus, the cytopathic LDV induces and maintains an inefficient immune response that is not exhausted. LDV infection in mice reveals a special type of host-virus equilibrium where LDV quickly establishes persistence despite continuously induced LDV-specific helper and cytotoxic T cell responses, which apparently are too slow to control the highly cytopathic and extremely fast replicating virus.
病毒已经发展出多种与脊椎动物宿主共存的策略。乳酸脱氢酶升高病毒（LDV）是一种具有高度细胞病变性的病毒，其复制速度极快；然而，LDV能建立持续感染且不损害宿主。在具有不同遗传背景的小鼠中监测了对LDV的细胞毒性和辅助性T细胞反应。在所有测试菌株中都发现了LDV特异性细胞毒性和辅助性T细胞。尽管血液中LDV水平很高，但这些反应至少持续了250天。因此，具有细胞病变性的LDV诱导并维持了一种低效且未耗竭的免疫反应。小鼠中的LDV感染揭示了一种特殊类型的宿主-病毒平衡，即尽管持续诱导产生LDV特异性辅助性和细胞毒性T细胞反应，但LDV仍能迅速建立持续感染，而这些反应显然太慢，无法控制这种具有高度细胞病变性且复制极快的病毒。
