McIntosh S, Fischer D B, Rothman S G, Rosenfield N, Lobel J S, O'Brien R
J Pediatr. 1977 Dec;91(6):909-13. doi: 10.1016/s0022-3476(77)80888-3.
Children with acute lymphocytic leukemia were examined for evidence of intracranial calcifications with roentgenograms of the skull and computerized tomography. Of 39 children in their initial complete remission, ten were found to have subcortical cerebral calcifications. Significant associations were found between the presence of cerebral calcifications and systemic treatment with large cumulative doses of methotrexate.
通过头颅X线平片和计算机断层扫描，对急性淋巴细胞白血病患儿进行颅内钙化证据检查。在39名处于首次完全缓解期的儿童中，发现10名有皮质下脑钙化。脑钙化的存在与大累积剂量甲氨蝶呤的全身治疗之间存在显著关联。
