Flament-Durand J, Ketelbant-Balasse P, Maurus R, Regnier R, Spehl M
Cancer. 1975 Feb;35(2):319-25. doi: 10.1002/1097-0142(197502)35:2<319::aid-cncr2820350205>3.0.co;2-3.
The authors present the case of a child aged 7 years who suffered from relapsing acute lymphocytic leukemia. Treatment consisting mainly of oral and intrathecal methotrexate and x-ray therapy produced remission of the hematologic symptoms. Three years after the onset of the leukemia, mental deterioration gradually appeared. Radiography of the skull revealed diffuse bilateral calcium deposits in both cerebral and cerebellar hemispheres. Four years after the onset of the disease, a hematologic relapse occurred. Behavioral disorders became more severe and the child died after a period of seizures and unconsciousness. The main pathologic data obtained by the study of a brain biopsy and after a complete postmortem examination consisted of calcifications located bilaterally in the cerebral and cerebellar cortex. No signs of leukemia were present. Cerebral calcification is an extremely rare complication in the course of the therapy of lymphocytic leukemia. Its possible causes are discussed.
作者报告了一名7岁患复发性急性淋巴细胞白血病儿童的病例。主要由口服和鞘内注射甲氨蝶呤及X线治疗组成的治疗使血液学症状得到缓解。白血病发病三年后，逐渐出现精神衰退。颅骨X线检查显示大脑和小脑半球双侧弥漫性钙沉积。疾病发病四年后，发生血液学复发。行为障碍变得更加严重，患儿在一阵癫痫发作和昏迷后死亡。通过脑活检研究及完整尸检获得的主要病理数据为双侧大脑和小脑皮质钙化。未发现白血病迹象。脑钙化是淋巴细胞白血病治疗过程中极其罕见的并发症。讨论了其可能的病因。
