Hsu C D, Copel J A, Chan D W
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520-8063, USA.
J Soc Gynecol Investig. 1997 May-Jun;4(3):135-7. doi: 10.1016/s1071-5576(97)00012-9.
To determine whether changes in plasma levels of thrombomodulin from antepartum to postpartum reflect the postpartum regression of preeclampsia.
Twenty-four preeclamptic women and 34 healthy, normotensive women with singleton pregnancies were studied in the third trimester. Plasma levels of thrombomodulin in the antepartum and postpartum periods were measured by a two-site immunoenzymatic assay. Two-tailed Student t test and paired-comparison t test were used for statistical analyses. The results were expressed as mean +/- standard error.
Antepartum plasma thrombomodulin levels in preeclampsia were significantly higher than postpartum levels (71.3 +/- 8.5 versus 55.5 +/- 5.4 ng/mL; P = .006), which was not seen in the normotensive controls (49.9 +/- 3.1 versus 44.2 +/- 3.8 ng/mL; P > .05). Antepartum plasma levels of thrombomodulin in preeclamptic women were significantly higher than those in the normotensive controls (P = .01). However, postpartum plasma levels of thrombomodulin in preeclamptic women were not significantly higher than those in the normotensive controls (P > .05).
Significantly decreased postpartum plasma thrombomodulin levels in preeclamptic pregnancies strongly correspond to clinical postpartum regression of preeclampsia.
确定从产前到产后血浆血栓调节蛋白水平的变化是否反映子痫前期产后的病情缓解。
对24名单胎妊娠的子痫前期妇女和34名健康、血压正常的单胎妊娠妇女在孕晚期进行研究。采用双位点免疫酶测定法测量产前和产后血浆血栓调节蛋白水平。采用双侧Student t检验和配对比较t检验进行统计分析。结果以平均值±标准误表示。
子痫前期患者产前血浆血栓调节蛋白水平显著高于产后水平（71.3±8.5对55.5±5.4 ng/mL；P = 0.006），而血压正常的对照组未出现这种情况（49.9±3.1对44.2±3.8 ng/mL；P>0.05）。子痫前期妇女产前血浆血栓调节蛋白水平显著高于血压正常的对照组（P = 0.01）。然而，子痫前期妇女产后血浆血栓调节蛋白水平并不显著高于血压正常的对照组（P>0.05）。
子痫前期妊娠产后血浆血栓调节蛋白水平显著降低与子痫前期临床产后病情缓解密切相关。
