Singhvi S M, Conway W D, Gibaldi M, Shaar S
J Pharm Sci. 1977 Oct;66(10):1488-9. doi: 10.1002/jps.2600661038.
Concomitant oral administration of salicylamide (200 mg/kg) and 3H-terbutaline (1 mg/kg) to rats with ligated bile ducts decreased absorption of terbutaline from the gut from 73 to 56% as measured by urinary excretion of radioactivity in 48 hr. No increase in the fraction of terbutaline excreted unchanged was observed, suggesting that salicylamide does not substantially inhibit the conjugation of terbutaline with glucuronic acid. An increase in the fraction of terbutaline excreted unchanged observed in normal animals may result from enhanced excretion of terbutaline glucuronide into bile rather than from inhibition of conjugation.
对胆管结扎的大鼠同时口服水杨酰胺（200毫克/千克）和3H-特布他林（1毫克/千克），通过48小时尿液放射性排泄测定，特布他林的肠道吸收从73%降至56%。未观察到特布他林原形排泄分数增加，这表明水杨酰胺不会显著抑制特布他林与葡萄糖醛酸的结合。正常动物中观察到的特布他林原形排泄分数增加可能是由于特布他林葡萄糖醛酸苷向胆汁中的排泄增强，而非结合抑制。
