Roscoe C W, Phillips J W, Gillchriest W C
J Pharm Sci. 1977 Oct;66(10):1505-7. doi: 10.1002/jps.2600661047.
An organoboron carboxamido derivative of tetracycline, designed for use in the 105B-thermal neutron-capture treatment of cancer, was synthesized under the conditions of the Mannich reaction using perhydro-2-phenyl-1,3,6,2-dioxazaborocine as the amine component. Spectral data (UV, IR, and NMR) for the compound and its hydrolytic stability are discussed.
一种用于癌症105B热中子俘获治疗的四环素有机硼羧酰胺衍生物，在曼尼希反应条件下，以全氢-2-苯基-1,3,6,2-二氧氮杂硼辛环作为胺组分合成得到。文中讨论了该化合物的光谱数据（紫外、红外和核磁共振）及其水解稳定性。
