Stezhka V V, Lovick T A
Department of Physiology, The Medical School, Birmingham, UK.
Neurosci Lett. 1997 Jul 11;230(1):57-60. doi: 10.1016/s0304-3940(97)00464-3.
In coronal slices of rat midbrain localised injections of FluoroGold or DiO into the dorsolateral periaqueductal grey matter (PAG) labelled cells retrogradely in the dorsal half of the dorsal raphe nucleus (DRN) and the ipsilateral ventrolateral PAG. Low intensity electrical stimulation in the dorsolateral PAG (22.9 +/- 1.9 microA) evoked antidromic responses in neurones recorded intracellularly in the dorsal subnucleus of the DRN. Antidromic responses could also be evoked in neurones in the ventral DRN and its wings but only at much higher currents (40.9 +/- 2.5 microA) which likely spread to activate axons in the ventrolateral PAG that originated from perikarya in the ventral DRN. The findings are discussed in relation to modulation of the excitability of the aversive system in the dorsolateral PAG by the DRN.
在大鼠中脑冠状切片中，向背外侧导水管周围灰质（PAG）局部注射荧光金或二碘辛酯，可逆行标记中缝背核（DRN）背侧半部和同侧腹外侧PAG中的细胞。背外侧PAG的低强度电刺激（22.9±1.9微安）在DRN背侧亚核内细胞内记录的神经元中诱发了逆向反应。在腹侧DRN及其侧翼的神经元中也可诱发逆向反应，但仅在高得多的电流（40.9±2.5微安）下，这可能会扩散以激活起源于腹侧DRN中胞体的腹外侧PAG中的轴突。结合DRN对背外侧PAG中厌恶系统兴奋性的调节对这些发现进行了讨论。
