Filoteo J V, Delis D C, Salmon D P, Demadura T, Roman M J, Shults C W
Department of Psychology, University of Utah, Salt Lake City 84112, USA.
J Int Neuropsychol Soc. 1997 Jul;3(4):337-47.
Endogenous and exogenous shifts of attention were examined in nondemented patients with Parkinson's disease (PD). In the endogenous condition, an arrow was used to cue participants' attention to the possible location of an impending target, whereas in the exogenous condition, a brightened box was used to cue attention. Cues were either valid (i.e., the target appeared in the cued location) or invalid (i.e., the target appeared in a noncued location). The time between cue onset and target onset (stimulus onset asynchrony or SOA) was varied in each condition. The results indicated that PD patients were not differentially impaired in shifting attention at the shorter SOAs relative to normal controls. However, at longer SOAs, the PD patients demonstrated less of an effect from cueing than did the normal control participants. PD patients' differential effect from cueing was evident in both exogenous and endogenous conditions. These results suggest that PD patients may experience a rapid decay of attentional inhibition and do not support the notion that a decrement in processing resources underlies their attentional deficits. Moreover, these findings further support the notion that the basal ganglia may play an important role in attentional functions.
对非痴呆帕金森病（PD）患者的内源性和外源性注意力转移进行了研究。在内源性条件下，使用箭头提示参与者将注意力指向即将出现的目标的可能位置，而在外源性条件下，使用变亮的方框提示注意力。提示要么有效（即目标出现在提示的位置），要么无效（即目标出现在未提示的位置）。在每种条件下，提示开始与目标开始之间的时间（刺激开始异步或SOA）是变化的。结果表明，与正常对照组相比，PD患者在较短的SOA下转移注意力时没有受到不同程度的损害。然而，在较长的SOA下，PD患者表现出的提示效应比正常对照组参与者要小。PD患者在提示方面的差异效应在外源性和内源性条件下均很明显。这些结果表明，PD患者可能经历注意力抑制的快速衰退，并且不支持加工资源减少是其注意力缺陷基础的观点。此外，这些发现进一步支持了基底神经节可能在注意力功能中起重要作用的观点。
