Cagigas Xavier E, Filoteo J Vincent, Stricker John L, Rilling Laurie M, Friedrich Frances J
SDSU/UCSD Joint Doctoral Program in Clinical Psychology, USA.
Brain Cogn. 2007 Apr;63(3):247-59. doi: 10.1016/j.bandc.2006.09.002. Epub 2006 Oct 17.
Parkinson's disease (PD) patients and healthy controls were administered a flanker task that consisted of the presentation of colored targets and distractors. Participants were required to attend to the center target and identify its color. The stimulus displays were either congruent (i.e., the target and flankers were the same color) or incongruent. The time between the onset of the flanker and the target color (the target onset delay) was either short or long. Results indicated that PD patients and controls did not differ in the magnitude of the flanker effect within individual trials in that both groups demonstrated a typical flanker effect at the short target onset delay and neither group demonstrated a flanker effect at the longer delay. However, when performance was examined on a trial-by-trial basis, PD patients demonstrated a slowing of reaction time relative to controls when having to make the same response across consecutive trials at longer inter-trial intervals when the flankers were incongruent across consecutive trials and the display on the second of two trials was incongruent. These results indicate that PD patients are impaired in inhibiting the distractors over an extended delay and that this deficit may impact motor responding in these patients, suggesting that the basal ganglia contribute to the interface of attention and action.
帕金森病（PD）患者和健康对照者接受了一项侧翼任务，该任务包括呈现彩色目标和干扰物。参与者需要关注中心目标并识别其颜色。刺激显示要么是一致的（即目标和侧翼是相同颜色），要么是不一致的。侧翼出现与目标颜色之间的时间间隔（目标起始延迟）要么短要么长。结果表明，在个体试验中，PD患者和对照组在侧翼效应的大小上没有差异，因为两组在短目标起始延迟时都表现出典型的侧翼效应，而在较长延迟时两组都没有表现出侧翼效应。然而，当逐次试验检查表现时，当侧翼在连续试验中不一致且两次试验中的第二次显示不一致时，在较长的试验间隔下，PD患者在连续试验中做出相同反应时，相对于对照组表现出反应时间减慢。这些结果表明，PD患者在长时间延迟抑制干扰物方面存在受损，并且这种缺陷可能会影响这些患者的运动反应，这表明基底神经节有助于注意力和行动的相互作用。
