de Aguiar P F, Vander Heyden Y V, Van Oost Y, Coomber T J, Massart D L
Chemo AC, Farmaceutisch Instituut, Vrije Universiteit Brussel, Belgium.
J Pharm Biomed Anal. 1997 Jul;15(11):1781-7. doi: 10.1016/s0731-7085(96)01967-x.
The optimisation of the separation of the antimalarial drugs, proguanil and atovaquone and six related compounds was obtained by two independent optimisation steps; the optimisation of the mobile phase composition and the optimisation of the pH. This was done using window selection diagrams (WSD) and a mixture design. The optimal conditions allow the identification of the six related compounds down to 0.1%.
通过两个独立的优化步骤实现了抗疟药物氯胍、阿托伐醌及六种相关化合物分离的优化；流动相组成的优化和pH值的优化。这是使用窗口选择图（WSD）和混合设计完成的。最佳条件可实现六种相关化合物低至0.1%的鉴定。
