Andant C, Puy H, Deybach J C, Soulé J C, Nordmann Y
Service d'hépato-gastroénterologie and Centre francais des porphyries(INSERM U 409), Hôpital Louis Mourier, Colombes, France.
Am J Gastroenterol. 1997 Aug;92(8):1389-90.
An association between two types of acute hepatic porphyria (porphyria variegata and acute intermittent porphyria) and hepatocellular carcinoma has previously been reported. In these studies, etiological factors for hepatocellular carcinoma were not completely sought. We report here the first case of an association between hepatocellular carcinoma and hereditary coproporphyria, the third type of acute hepatic porphyria. A 58-yr-old woman with hereditary coproporphyria presented with a 3.5-cm-diameter hepatocellular carcinoma. Results of exhaustive investigation of etiological factors for hepatocellular carcinoma were negative. Results of microscopic histological analysis of the nontumorous liver were normal. Five years after surgical resection, the patient had no evidence of tumor recurrence.
先前已有报道称两种急性肝卟啉症（杂色卟啉症和急性间歇性卟啉症）与肝细胞癌之间存在关联。在这些研究中，并未全面探寻肝细胞癌的病因。我们在此报告首例肝细胞癌与遗传性粪卟啉症（第三种急性肝卟啉症）之间存在关联的病例。一名患有遗传性粪卟啉症的58岁女性出现了直径为3.5厘米的肝细胞癌。对肝细胞癌病因进行全面调查的结果为阴性。非肿瘤性肝脏的显微组织学分析结果正常。手术切除五年后，该患者没有肿瘤复发的迹象。
