Cho S J, Sohn Y H, Kim G W, Kim J S
Department of Neurology and the Brain Research Institute, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Korea.
J Neurol Sci. 1997 Sep 1;150(1):77-80. doi: 10.1016/s0022-510x(97)05391-4.
This study was designed to demonstrate cerebral hemodynamic changes related to hypertension using transcranial Doppler ultrasonography. We measured the flow velocities and the Gosling pulsatility index of the middle cerebral artery and the internal carotid artery in 94 stroke-free, hypertensive patients and 81 age- and gender-matched healthy controls. Compared with the control subjects, patients with a longer duration (> or = 5 years) of hypertension showed significantly lower flow velocities of the middle cerebral artery and a higher Gosling pulsatility index of the middle cerebral- and the internal carotid artery. These differences were not observed in patients with a shorter duration of hypertension (<5 years). In the patient group, the mean velocity of the middle cerebral artery was significantly and inversely correlated with the duration of hypertension. Decreased flow velocity with increased pulsatility observed in this study suggest that alterations in the small cerebral vessels and arterioles contribute primarily to cerebral hemodynamic changes occurring in long-standing hypertension and also suggest the possible usefulness of transcranial Doppler in monitoring the progression of cerebral atherogenesis related to hypertension.
本研究旨在利用经颅多普勒超声检查来证明与高血压相关的脑血流动力学变化。我们测量了94例无中风的高血压患者以及81例年龄和性别匹配的健康对照者的大脑中动脉和颈内动脉的血流速度及戈斯林搏动指数。与对照组相比，高血压病程较长（≥5年）的患者大脑中动脉血流速度显著降低，大脑中动脉和颈内动脉的戈斯林搏动指数较高。高血压病程较短（<5年）的患者未观察到这些差异。在患者组中，大脑中动脉的平均速度与高血压病程显著负相关。本研究中观察到的血流速度降低和搏动性增加表明，大脑小血管和小动脉的改变主要导致长期高血压中发生的脑血流动力学变化，也表明经颅多普勒在监测与高血压相关的脑动脉粥样硬化进展方面可能有用。
