大肠杆菌组成型活性增强子结合蛋白PspF的自体调控
Autogenous control of PspF, a constitutively active enhancer-binding protein of Escherichia coli.
作者信息
Jovanovic G, Dworkin J, Model P
机构信息
Laboratory of Genetics, The Rockefeller University, New York, New York 10021, USA.
出版信息
J Bacteriol. 1997 Aug;179(16):5232-7. doi: 10.1128/jb.179.16.5232-5237.1997.
Abstract
Escherichia coli sigma54-dependent phage shock protein operon (pspA to -E) transcription is under the control of PspF, a constitutively active activator. Sigma70-dependent transcription of pspF is under autogenous control by wild-type PspF but not by a DNA-binding mutant, PspF deltaHTH. Negative autoregulation of PspF is continual and not affected by stimuli, like f1 pIV, that induce the pspA to -E operon. PspF production is independent of PspA (the negative regulator of the pspA to -E operon) and of PspB and -C (positive regulators).
摘要
大肠杆菌σ54依赖性噬菌体休克蛋白操纵子（pspA至-E）的转录受PspF控制，PspF是一种组成型活性激活因子。pspF的σ70依赖性转录受野生型PspF的自身调控，但不受DNA结合突变体PspF deltaHTH的调控。PspF的负向自身调节是持续的，不受诱导pspA至-E操纵子的刺激（如f1 pIV）的影响。PspF的产生独立于PspA（pspA至-E操纵子的负调节因子）以及PspB和-C（正调节因子）。
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