Marshall K A, Robertson M P, Ellington A D
Department of Chemistry, Indiana University, Bloomington 47405, USA.
Structure. 1997 Jun 15;5(6):729-34. doi: 10.1016/s0969-2126(97)00227-x.
Crystal structures have recently been reported for several in vitro selected aptamers that bind small molecules. A structural comparison of these aptamers with proteins that bind identical ligands reveals similar strategies for forming ligand-binding pockets.
最近有报道称已获得了几种结合小分子的体外筛选适配体的晶体结构。将这些适配体与结合相同配体的蛋白质进行结构比较,结果显示它们在形成配体结合口袋方面采用了相似的策略。