接受丙戊酸钠单药治疗的癫痫患者的听觉事件相关电位
Auditory event related potentials in patients with epilepsy on sodium valproate monotherapy.
作者信息
Panagopoulos G R, Thomaides T, Tagaris G, Karageorgiou C L
机构信息
Department of Neurology, Athens General Hospital, Greece.
出版信息
Acta Neurol Scand. 1997 Jul;96(1):62-4. doi: 10.1111/j.1600-0404.1997.tb00240.x.
OBJECTIVES
The effects of antiepileptic drugs on event related potentials (ERPs) have been studied, but with contradictory results. In this study we examine the effect of sodium valproate (VPA) on ERPs in patients with epilepsy.
MATERIALS AND METHODS
Auditory event related potentials were recorded in 40 patients with idiopathic generalized epilepsy, 20 on monotherapy with sodium valproate (VPA), 20 on monotherapy with carbamazepine and 20 age and sex matched controls. All subjects performed a simple auditory discrimination task in which a target tone was presented on 20% of the trials.
RESULTS
Mean P3 latency of the VPA group was significantly prolonged but not in carbamazepine group and healthy controls.
CONCLUSION
We conclude that VPA monotherapy has an effect on P300 latency in patients with epilepsy. This difference might be attributed to effects of treatment with VPA and may clarify in the future the mechanism of P300.
目的
抗癫痫药物对事件相关电位（ERP）的影响已得到研究，但结果相互矛盾。在本研究中，我们检验丙戊酸钠（VPA）对癫痫患者ERP的影响。
材料与方法
记录40例特发性全身性癫痫患者的听觉事件相关电位，其中20例采用丙戊酸钠（VPA）单药治疗，20例采用卡马西平单药治疗，20例为年龄和性别匹配的对照者。所有受试者均执行一项简单的听觉辨别任务，其中20%的试验中会呈现目标音调。
结果
VPA组的平均P3潜伏期显著延长，但卡马西平组和健康对照组未出现这种情况。
结论
我们得出结论，VPA单药治疗对癫痫患者的P300潜伏期有影响。这种差异可能归因于VPA治疗的效果，未来可能会阐明P300的机制。
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