环孢素A治疗成人斯蒂尔病
Cyclosporin A in the treatment of adult onset Still's disease.
作者信息
Marchesoni A, Ceravolo G P, Battafarano N, Rossetti A, Tosi S, Fantini F
机构信息
Rheumatology Unit, University of Milan, G. Pini Orthopaedic Institute, Italy.
出版信息
J Rheumatol. 1997 Aug;24(8):1582-7.
OBJECTIVE
To determine whether cyclosporin A (CyA) is a useful option in the treatment of adult onset Still's disease (ASD).
METHODS
Low dose CyA was given to 6 patients with chronic or relapsing ASD who had not been prescribed any other second line agents during the previous 6 mo.
RESULTS
The disease completely remitted in 4 patients and improved markedly in the remaining 2. The corticosteroid requirement was substantially reduced in all cases. Tolerability was rated good or very good by all patients but one, who reported good tolerance to CyA only in a new formulation.
CONCLUSION
CyA may be included among the second line agents used in the treatment of refractory ASD.
目的
确定环孢素A（CyA）是否是治疗成人斯蒂尔病（ASD）的有效选择。
方法
对6例慢性或复发性ASD患者给予低剂量CyA，这些患者在之前6个月内未使用过任何其他二线药物。
结果
4例患者疾病完全缓解，其余2例明显改善。所有病例中皮质类固醇的需求量均大幅减少。除1例患者外，所有患者对耐受性的评价为良好或非常好，该例患者仅对新剂型的CyA耐受性良好。
结论
CyA可纳入用于治疗难治性ASD的二线药物之中。
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