Duyckaerts C, Bennecib M, Grignon Y, Uchihara T, He Y, Piette F, Hauw J J
Raymond Escourolle Neuropathology Laboratory, INSERM U360 & Association Claude Bernard, La Salpêtrière Hospital, Paris, France.
Neurobiol Aging. 1997 May-Jun;18(3):267-73. doi: 10.1016/s0197-4580(97)80306-5.
The relationship between the neurofibrillary tangles and the intellectual deficit observed in senile dementia of the Alzheimer type was studied in 27 patients over the age of 75. The presence and density of tau positive tangles were assessed in six areas including limbic, paralimbic, and isocortical cortices. In the isocortical areas, the presence [1] or absence [0] of neurofibrillary tangles was better correlated with the Blessed test score than the density of the neurofibrillary tangles profiles. Multivariate analysis showed that the number of areas containing at least one neurofibrillary tangle was the best explanatory variable of the intellectual status. The cortical areas were ranked according to the prevalence of their involvement. The presence of tangles in an area of a given rank took place only if the areas of lower ranks were also involved. It is proposed that the presence of tangles in a given area is a more significant information than the value of their density. These data may lead to new diagnostic procedures.
对27名75岁以上的患者研究了阿尔茨海默型老年痴呆症中神经原纤维缠结与智力缺陷之间的关系。在包括边缘叶、边缘旁叶和等皮质皮质在内的六个区域评估tau阳性缠结的存在和密度。在等皮质区域，神经原纤维缠结的存在[1]或不存在[0]与Blessed测试评分的相关性比神经原纤维缠结轮廓的密度更好。多变量分析表明，包含至少一个神经原纤维缠结的区域数量是智力状态的最佳解释变量。根据皮质区域受累的患病率对其进行排名。仅当较低排名的区域也受累时，给定排名区域才会出现缠结。有人提出，给定区域中缠结的存在比其密度值更具重要信息。这些数据可能会带来新的诊断程序。
