Károly Schaffer Laboratory of Neuropathology, Department of Neurology, Semmelweis University Balassa u. 6. H-1083 Budapest, Hungary.
Curr Alzheimer Res. 2013 Oct;10(8):818-28. doi: 10.2174/15672050113109990153.
In Alzheimer's disease (AD), neurofibrillary degeneration in the hemispheres starts in the limbic and paralimbic regions prior to those in the isocortical ones but factors determining the progression of these changes are unknown. Previous studies have shown that migration of extracellular substances (volume transmission) driven by arterial pulse pressure waves from the cerebrospinal fluid (CSF) towards the brain parenchyma occurs earlier in these limbic and paralimbic cortices located around the basal cisterns containing the proximal segments of the main hemispheric arteries than in the isocortex. Considering this similarity, the aim of our study was to examine the relation between the proximal segments of the main hemispheric arteries and the development and spread of neurofibrillary tangles (NFTs) in limbic and early isocortical Braaks' stages. Blocks following proximosdistal levels of the anterior and middle cerebral arteries containing areas of the cingulate and insular cortices, respectively, were dissected and NFTs were counted. In both regions, the density of NFTs decreased in parallel with the proximodistal segments of the accompanying arteries. Our results show that neurofibrillary degeneration in AD is related to the proximodistal levels of the main hemispheric arteries and raise the possibility that this effect is mediated by volume transmission from the CSF into the brain.
在阿尔茨海默病（AD）中，半球内的神经纤维变性首先发生在边缘和旁边缘区域，然后才发生在等皮质区域，但决定这些变化进展的因素尚不清楚。先前的研究表明，由动脉脉搏压力波从脑脊液（CSF）驱动的细胞外物质（容积传递）向脑实质的迁移，在这些位于包含大脑主要动脉近端节段的基底池周围的边缘和旁边缘皮质中比在等皮质中更早发生。考虑到这种相似性，我们研究的目的是检查大脑主要动脉的近端节段与神经原纤维缠结（NFTs）在边缘和早期等皮质 Braaks 阶段的发展和扩散之间的关系。分别沿着大脑前动脉和大脑中动脉的近-远水平解剖包含扣带回和岛叶皮质区域的脑块，并计数 NFTs。在这两个区域，NFTs 的密度与伴随动脉的近-远节段平行下降。我们的结果表明，AD 中的神经纤维变性与大脑主要动脉的近-远水平有关，并提出这种影响可能是由 CSF 向脑内的容积传递介导的。
