Díaz-Otañez C S, Capriles N R, Cancela L M
Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina.
Pharmacol Biochem Behav. 1997 Sep;58(1):9-14. doi: 10.1016/s0091-3057(96)00344-9.
The time course of the restraint stress-induced sensitization to the stimulant effects of amphetamine (AMPH, 0.5 mg/kg IP) on locomotor activity was investigated for up to 8 days. In a series of separate experiments, the involvement of opioid and dopaminergic mechanisms in the development of acute restraint stress-induced behavioral sensitization were characterized. Both a single restraint session (2 h) and chronic restraint (2 h per day for 7 days) similarly potentiated the effects of AMPH on motor activity. This behavioral sensitization was prevented by the administration of naltrexone (2 mg/kg IP), haloperidol (1 mg/kg IP), sulpiride (60 mg/kg IP) or SCH23390 (0.5 mg/kg IP) 10-20 min prior to restraint. These results indicate that 1) the development of sensitization to amphetamine-induced effects on motor activity does not depend on the length of exposure to stress (acute or chronic). 2) the stimulation of both D1 and D2 dopaminergic receptors is necessary for the development of the restraint stress-induced sensitization to AMPH and 3) and opioid system is also implicated in this sensitization process.
研究了束缚应激诱导对苯丙胺（AMPH，0.5mg/kg腹腔注射）对运动活动的兴奋作用的敏感性的时程，长达8天。在一系列单独的实验中，对阿片类和多巴胺能机制在急性束缚应激诱导的行为敏化发展中的作用进行了表征。单次束缚（2小时）和慢性束缚（每天2小时，共7天）同样增强了AMPH对运动活动的作用。在束缚前10 - 20分钟给予纳曲酮（2mg/kg腹腔注射）、氟哌啶醇（1mg/kg腹腔注射）、舒必利（60mg/kg腹腔注射）或SCH23390（0.5mg/kg腹腔注射）可预防这种行为敏化。这些结果表明：1）对苯丙胺诱导的运动活动作用的敏化发展不依赖于应激暴露的时长（急性或慢性）；2）D1和D2多巴胺能受体的刺激对于束缚应激诱导的对AMPH的敏化发展是必要的；3）阿片系统也参与了这种敏化过程。
