Chen C H, Lee Y R, Wei F C, Koong F J, Hwu H G, Hsiao K J
Division of Neuropsychiatry, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Psychiatr Genet. 1997 Spring;7(1):35-8. doi: 10.1097/00041444-199700710-00005.
Recent studies have reported an association between a 102T/C polymorphism of serotonin receptor type 2A gene (5-HT2A) and schizophrenia. In addition, an association was detected between a 102T/C polymorphism of the 5-HT2A receptor gene and drug response to clozapine in the treatment of schizophrenic patients. These studies suggest an important role of the 5-HT2A gene in schizophrenia. To study the possible involvement of the 5-HT2A gene in the pathogenesis of schizophrenia, a case-control association study was carried out in a Chinese population from Taiwan. No significant differences of genotype distributions, allele frequencies and homozygosity were detected between schizophrenic patients (n = 177) and nonpsychiatric controls (n = 98). When subjects were divided into subgroups according to sex, still no differences of allele frequencies or genotype distributions were noted between patients and controls. Our data do not support an allelic association between the 102T/C polymorphism of the 5-HT2A receptor gene and schizophrenia in Chinese population.
近期研究报道了血清素2A型受体基因（5-HT2A）的102T/C多态性与精神分裂症之间的关联。此外，在精神分裂症患者的治疗中，检测到5-HT2A受体基因的102T/C多态性与氯氮平的药物反应之间存在关联。这些研究表明5-HT2A基因在精神分裂症中起重要作用。为了研究5-HT2A基因可能参与精神分裂症的发病机制，在台湾的中国人群中进行了一项病例对照关联研究。在精神分裂症患者（n = 177）和非精神科对照者（n = 98）之间，未检测到基因型分布、等位基因频率和纯合性的显著差异。当根据性别将受试者分为亚组时，患者与对照者之间的等位基因频率或基因型分布仍无差异。我们的数据不支持中国人群中5-HT2A受体基因的102T/C多态性与精神分裂症之间存在等位基因关联。
