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[腹部脓肿:其治疗及预后因素研究]

[Abdominal abscesses: their treatment and the study of prognostic factors].

作者信息

Giangreco L, Di Palo S, Castrucci M, Angeli E, Staudacher C

机构信息

Università di Milano, IRCCS S. Raffaele.

出版信息

Minerva Chir. 1997 Apr;52(4):369-76.

PMID:9265119
Abstract

The aim of this study is to define outcome predictors that might influence the prognosis and the mortality rate either of percutaneous drainage (DP) or open surgical drainage (DC) for abdominal abscesses. Seventy-one patients with 81 intra-abdominal abscesses were prospectively studied. They were 40 males and 31 females. Mean age was 47 +/- 15 years. Thirty-six (50.7%) patients had a simple abscess, while 35 (49.2%) had a complex abscess. Abscesses occurred most commonly in the sub-hepatic area, pelvic and para-colic space. Thirty-two (45%) patients had a percutaneous drainage, while 39 (54.9%) underwent an operative drainage management. Criteria for treatment selection were not randomized. However the two groups were statistically similar in respect to clinical features, cirrhosis, nutritional status, APACHE II scores), genesis and characteristics (simple, complex) of the abscesses. The treatment was considered successful when not requiring further drainage and the patient survived. Abdominal abscesses were cured in 53 (74.6) patients. In 13 cases (18.3%) a further drainage was necessary to obtain a complex resolution. Post drainage complications were significantly higher in the surgical drainage group (38.4% vs 12%, p < 0.05) because of the high incidence of wound infections. The overall mortality rate was 7%. Using an univariate analysis model, the only significant variable related to unsuccessful outcome in both the percutaneous and surgical group was abscess complexity (p < 0.005). Elderly (p < 0.005), malnutrition (p < 0.03), presence of cancer (p < 0.05), a high APACHE II score (p < 0.005) and the presence of a complex abscess (p < 0.02) were significantly identified as determinants of death.

摘要

本研究的目的是确定可能影响腹腔脓肿经皮引流(DP)或开放手术引流(DC)的预后及死亡率的预后预测因素。对71例患有81个腹腔内脓肿的患者进行了前瞻性研究。其中男性40例,女性31例。平均年龄为47±15岁。36例(50.7%)患者为单纯性脓肿,35例(49.2%)为复杂性脓肿。脓肿最常见于肝下区域、盆腔和结肠旁间隙。32例(45%)患者接受了经皮引流,39例(54.9%)接受了手术引流治疗。治疗选择标准未随机化。然而,两组在临床特征、肝硬化、营养状况、急性生理与慢性健康状况评分系统(APACHE II)评分、脓肿的起源和特征(单纯性、复杂性)方面在统计学上相似。当不需要进一步引流且患者存活时,治疗被认为是成功的。53例(74.6%)患者的腹腔脓肿得以治愈。13例(18.3%)患者需要进一步引流以实现复杂的治愈。由于伤口感染发生率高,手术引流组的引流后并发症显著更高(38.4%对12%,p<0.05)。总死亡率为7%。使用单因素分析模型,在经皮和手术组中,与治疗失败相关的唯一显著变量是脓肿的复杂性(p<0.005)。老年人(p<0.005)、营养不良(p<0.03)、存在癌症(p<0.05)、高APACHE II评分(p<0.005)以及存在复杂性脓肿(p<0.02)被显著确定为死亡的决定因素。

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