Ziangirova G G, Bocharov V E, Malaeva L V, Olinevich V B, Sherstnev V V
NII of Eye Diseases, RAMN, Moscow.
Vestn Oftalmol. 1997 May-Jun;113(3):26-9.
The effect of synthetic peptide ACTH4-10 on the course of healing of an experimental wound of the rabbit cornea was studied. Daily subconjunctival injections of the drug in a dose of 10(-8) M for 25 days boosted the migration of leukocytes and macrophages and increased the interstitial and keratocyte proteolysis during the first 10 days of the experiment. Subsequent follow-up showed manifest proliferation of fibroblasts and formation of fibrosis. These data demonstrate expressed effect of synthetic ACTH4-10 on the course of the inflammatory and regeneratory processes in the cornea after partial keratectomy and prove the possibility of short-term local therapy with this peptide as an agent improving corneal wound healing during the initial phases.
研究了合成肽促肾上腺皮质激素4 - 10对兔角膜实验性伤口愈合过程的影响。在实验的前10天，每天以10(-8) M的剂量结膜下注射该药物，持续25天，可促进白细胞和巨噬细胞的迁移，并增加间质和角膜细胞的蛋白水解作用。随后的随访显示成纤维细胞明显增殖并形成纤维化。这些数据表明合成促肾上腺皮质激素4 - 10对部分角膜切除术后角膜炎症和再生过程有明显作用，并证明了用该肽进行短期局部治疗作为一种在初始阶段改善角膜伤口愈合的药物的可能性。
