Oganov R G, Vinogradova I V, Aleksandrov A A
Kardiologiia. 1977 Aug;17(8):70-3.
In 14 patients with ischaemic heart disease the plasma noradrenaline and adrenalin levels were determined during anginal attacks and in the attack-free period, and daily catecholamines excretion was studied in 11 of them. The blood plasma and urine noradrenaline and adrenalin levels were determined with the help of the trioxyindol, fluorimetric method. The content of noradrenaline and adrenalin in the blood plasma during anginal attacks was statistically significantly higher than during the attack-free period. At the same time, in urine samples collected during 24 hours after the attack and during an attack-free period no significant differences in the concentration of both catecholamines was found. Consequently, hypercatecholaminemia observed during anginal attacks is brief. An elevation of the activity of the sympathodrenal system may favour the development of rhythm disorders and hamper the therapeutic measures.
对14例缺血性心脏病患者,在心绞痛发作期间和无发作期测定其血浆去甲肾上腺素和肾上腺素水平,并对其中11例患者的每日儿茶酚胺排泄情况进行了研究。采用三羟吲哚荧光法测定血浆和尿液中的去甲肾上腺素和肾上腺素水平。心绞痛发作时血浆中去甲肾上腺素和肾上腺素的含量在统计学上显著高于无发作期。同时,在发作后24小时收集的尿液样本和无发作期收集的尿液样本中,两种儿茶酚胺的浓度均未发现显著差异。因此,心绞痛发作时观察到的高儿茶酚胺血症是短暂的。交感肾上腺系统活性的升高可能有利于心律失常的发生,并妨碍治疗措施。