Belenkov Iu N, At'kov O Iu, Tsibekmakher T D
Kardiologiia. 1977 Sep;17(9):46-50.
The article deals with the data of echocardiographic examination of 61 patients (37 with rheumatic heart disease and 17 with atherosclerotic cardiosclerosis) subjected to rapid stage-by-stage digitalization by intravenous administration of various rapidly acting glycosides. In 10 patients with ischemic heart disease echocardiography was performed following a single strophanthin injection. Decrease in the volumes of the left ventricle and increase in the indices of central hemodynamics were noted as a result of rapid stage-by-stage saturation with strophanthin. The maximum inotropic effect of strophanthin does not coincide in time with the maximum chronotropic effect. The increase in the stroke volume noted in maximum deceleration of cardiac contractions is probably realized due to the Frank-Starling mechanism. Strophanthin increases the rate of myocardial contractions without changing the duration of the systole. The rate of diastolic relaxation grows, the phase of rapid filling becomes shorter and the phase of slow filling longer, which creates favourable conditions for the next contraction.
本文探讨了对61例患者（37例风湿性心脏病患者和17例动脉粥样硬化性心脏病患者）进行超声心动图检查的数据，这些患者通过静脉注射各种速效强心苷进行快速逐阶段数字化处理。对10例缺血性心脏病患者在单次注射毒毛花苷后进行了超声心动图检查。毒毛花苷快速逐阶段饱和的结果是左心室容积减小，中心血流动力学指标增加。毒毛花苷的最大正性肌力作用与最大变时性作用在时间上不一致。在心脏收缩最大减速时观察到的每搏输出量增加可能是由于Frank-Starling机制实现的。毒毛花苷增加心肌收缩速率而不改变收缩期持续时间。舒张期松弛速率增加，快速充盈期变短，缓慢充盈期变长，这为下一次收缩创造了有利条件。
