Zisman A, Soffer Y, Siegel Y I, Paz A, Lindner A
Department of Urology, Assaf Harofeh Medical Center, Zerifin, Israel.
Eur Urol. 1997;32(1):54-7.
This study was carried out to determine whether ejaculation may modify the serum prostate-specific antigen (PSA) level and to investigate whether postejaculation serum PSA may play a role in male hypofertility work-up.
Serum PSA concentration was determined before and 1 h after ejaculation in 18 healthy men (group A) and in 16 men with male-factor infertility (group B). PSA change (delta) was recorded and analyzed.
Postejaculation serum PSA differed significantly from basal levels (p = 0.0037 by the Wilcoxon signed rank test). Following ejaculation, a rise was noticed in 74% of subjects. The median relative change in PSA concentration was 54%. No difference in respect to mean, median and relative change was observed between study groups. In two cases (6%), PSA rose from normal level to more than 4 ng/ml.
A significant postejaculation serum PSA elevation does occur, it is thus recommended that men abstain from ejaculation for 24 h prior to PSA sampling. Postejaculation PSA was not found to significantly correlate with hypofertility.
本研究旨在确定射精是否会改变血清前列腺特异性抗原（PSA）水平，并探讨射精后血清PSA是否在男性不育症检查中发挥作用。
对18名健康男性（A组）和16名男性因素不育症患者（B组）在射精前和射精后1小时测定血清PSA浓度。记录并分析PSA变化（delta）。
射精后血清PSA与基础水平有显著差异（Wilcoxon符号秩检验，p = 0.0037）。射精后，74%的受试者出现升高。PSA浓度的中位数相对变化为54%。研究组之间在均值、中位数和相对变化方面未观察到差异。在两例（6%）中，PSA从正常水平升至超过4 ng/ml。
射精后血清PSA确实会显著升高，因此建议男性在PSA采样前24小时避免射精。未发现射精后PSA与不育症有显著相关性。
