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The activity of dihydropyrimidine dehydrogenase in human blood cells.

作者信息

Van Kuilenburg A B, Blom M J, Van Lenthe H, Mul E, Van Gennip A H

机构信息

University of Amsterdam, Department of Pediatrics, The Netherlands.

出版信息

J Inherit Metab Dis. 1997 Jul;20(3):331-4. doi: 10.1023/a:1005305323052.

DOI:10.1023/a:1005305323052
PMID:9266348
Abstract
摘要

相似文献

1
The activity of dihydropyrimidine dehydrogenase in human blood cells.人血细胞中二氢嘧啶脱氢酶的活性
J Inherit Metab Dis. 1997 Jul;20(3):331-4. doi: 10.1023/a:1005305323052.
2
Porcine recombinant dihydropyrimidine dehydrogenase: comparison of the spectroscopic and catalytic properties of the wild-type and C671A mutant enzymes.猪重组二氢嘧啶脱氢酶：野生型和C671A突变体酶的光谱和催化特性比较。
Biochemistry. 1998 Dec 15;37(50):17598-609. doi: 10.1021/bi9815997.
3
The activity of dihydropyrimidine dehydrogenase in human blood cells.人血细胞中二氢嘧啶脱氢酶的活性
Adv Exp Med Biol. 1998;431:823-6. doi: 10.1007/978-1-4615-5381-6_158.
4
Stereochemistry of NADPH oxidation by dihydropyrimidine dehydrogenase from pig liver.猪肝二氢嘧啶脱氢酶催化NADPH氧化的立体化学
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5
New high-performance liquid chromatographic method for the determination of low activities of dihydropyrimidine dehydrogenase.用于测定二氢嘧啶脱氢酶低活性的新型高效液相色谱法。
J Chromatogr. 1990 Aug 3;529(2):431-6. doi: 10.1016/s0378-4347(00)83850-5.
6
Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity.二氢嘧啶脱氢酶家族性缺乏。家族性嘧啶血症和严重5-氟尿嘧啶诱导毒性的生化基础。
J Clin Invest. 1988 Jan;81(1):47-51. doi: 10.1172/JCI113308.
7
Comparative study of thymine and uracil metabolism in healthy persons and in a patient with dihydropyrimidine dehydrogenase deficiency.
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Analysis of the dihydropyrimidine dehydrogenase polymorphism in a British population.英国人群中二氢嘧啶脱氢酶多态性分析。
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[Diaphorasic NADPH and NADH systems in human blood cells].
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Semi-automated radioassay for determination of dihydropyrimidine dehydrogenase (DPD) activity. Screening cancer patients for DPD deficiency, a condition associated with 5-fluorouracil toxicity.
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Pharmaceutics. 2024 Jul 19;16(7):956. doi: 10.3390/pharmaceutics16070956.
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Evolution of Dihydropyrimidine Dehydrogenase Diagnostic Testing in a Single Center during an 8-Year Period of Time.单中心8年期间二氢嘧啶脱氢酶诊断检测的演变
Curr Ther Res Clin Exp. 2018 Oct 31;90:1-7. doi: 10.1016/j.curtheres.2018.10.001. eCollection 2019.
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Biochemical abnormalities in a patient with thymidine phosphorylase deficiency with fatal outcome.

本文引用的文献

1
Identification and tissue-specific expression of a NADH-dependent activity of dihydropyrimidine dehydrogenase in man.
Anticancer Res. 1996 Jan-Feb;16(1):389-94.
2
Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy.人外周血单个核细胞和肝脏中的二氢嘧啶脱氢酶活性：群体特征、新发现的缺陷患者以及5-氟尿嘧啶化疗的临床意义
Cancer Res. 1993 Nov 15;53(22):5433-8.
3
Clinical and biochemical findings in six patients with pyrimidine degradation defects.
J Inherit Metab Dis. 1994;17(1):130-2. doi: 10.1007/BF00735416.
4
胸苷磷酸化酶缺陷患者的生化异常及其致死结局。
J Inherit Metab Dis. 2010 Dec;33 Suppl 3(Suppl 3):S139-43. doi: 10.1007/s10545-010-9049-y. Epub 2010 Feb 12.
4
Severe 5-fluorouracil toxicity caused by reduced dihydropyrimidine dehydrogenase activity due to heterozygosity for a G-->A point mutation.
J Inherit Metab Dis. 1998 Jun;21(3):280-4. doi: 10.1023/a:1005384609289.
Catabolism of exogenously supplied thymidine to thymine and dihydrothymine by platelets in human peripheral blood.人外周血中的血小板将外源性供给的胸苷分解代谢为胸腺嘧啶和二氢胸腺嘧啶。
Cancer Res. 1984 Nov;44(11):4955-61.
5
Elevated urine, blood and cerebrospinal fluid levels of uracil and thymine in a child with dihydrothymine dehydrogenase deficiency.一名患有二氢胸腺嘧啶脱氢酶缺乏症的儿童尿液、血液和脑脊液中尿嘧啶和胸腺嘧啶水平升高。
Clin Chim Acta. 1984 Jul 31;140(3):247-56. doi: 10.1016/0009-8981(84)90206-7.
6
Enzymes of uracil catabolism in normal and neoplastic human tissues.正常和肿瘤性人类组织中尿嘧啶分解代谢的酶
Cancer Res. 1985 Nov;45(11 Pt 1):5405-12.
7
Metabolic comparison between basophils and other leukocytes from human blood.人类血液中嗜碱性粒细胞与其他白细胞之间的代谢比较。
J Immunol. 1986 May 1;136(9):3447-54.
8
Clinical pharmacology of 5-fluorouracil.5-氟尿嘧啶的临床药理学
Clin Pharmacokinet. 1989 Apr;16(4):215-37. doi: 10.2165/00003088-198916040-00002.