Porcu P, Danielson C F, Orazi A, Heerema N A, Gabig T G, McCarthy L J
Department of Medicine, Indiana University Medical Center, Indianapolis 46202-5283, U.S.A.
Br J Haematol. 1997 Aug;98(2):433-6. doi: 10.1046/j.1365-2141.1997.1943011.x.
The clinical and laboratory data of 48 leukapheresis-treated patients with hyperleucocytic leukaemia (HL) was reviewed to assess the correlation between the degree of leucoreduction and early mortality. Leukapheresis resulted in > 50% leucoreductions and postapheresis WBC counts < 100 x 10(9)/l in most patients (64.5%). Patients presenting with neurological, respiratory or renal complications had higher early mortality rates than patients without such complications, despite similar initial WBC counts and comparable leucoreductions. Thus, in these patients, more efficient leucoreduction was not associated with improved early survival.
回顾了48例接受白细胞单采术治疗的高白细胞血症（HL）患者的临床和实验室数据，以评估白细胞去除程度与早期死亡率之间的相关性。大多数患者（64.5%）进行白细胞单采术后白细胞减少>50%，且采后白细胞计数<100×10⁹/L。出现神经、呼吸或肾脏并发症的患者早期死亡率高于无此类并发症的患者，尽管初始白细胞计数相似且白细胞去除程度相当。因此，在这些患者中，更有效的白细胞去除与早期生存率的改善无关。
