染色体1、3、7和8频繁参与脾边缘区B细胞淋巴瘤的发生。

Frequent involvement of chromosomes 1, 3, 7 and 8 in splenic marginal zone B-cell lymphoma.

作者信息

Solé F, Woessner S, Florensa L, Espinet B, Mollejo M, Martín P, Piris M A

机构信息

Laboratori de Citologia Hematológica, Unitat d'Hematologia i Oncologia1973, Hospital Central l'Aliança, Barcelona, Spain.

出版信息

Br J Haematol. 1997 Aug;98(2):446-9. doi: 10.1046/j.1365-2141.1997.2163033.x.

DOI:10.1046/j.1365-2141.1997.2163033.x

PMID:9266948

Abstract

We have studied 19 cases of splenic marginal zone B-cell lymphoma (SMZBCL) combining cytological features, conventional cytogenetics, and in situ hybridization (ISH) techniques. A clonal chromosome abnormality was found in 11/19 patients (58%). The more frequent recurrent abnormalities were: del(3), del (7q), and involvement of chromosomes 1, 3, 7 and 8. No patient showed the translocation t(11;14)(q13;q32). An outstanding finding was the low incidence of trisomy 3 (36%) compared to patients with MALT lymphoma. These findings support the interpretation that SMZBCL is a distinct lymphoproliferative disorder.

摘要

我们结合细胞学特征、传统细胞遗传学和原位杂交（ISH）技术研究了19例脾边缘区B细胞淋巴瘤（SMZBCL）。11/19例患者（58%）发现有克隆性染色体异常。较常见的复发性异常为：3号染色体缺失、7号染色体长臂缺失以及1、3、7和8号染色体受累。无一例患者出现t(11;14)(q13;q32)易位。一个显著的发现是，与黏膜相关淋巴组织（MALT）淋巴瘤患者相比，3号染色体三体的发生率较低（36%）。这些发现支持了SMZBCL是一种独特的淋巴增殖性疾病的解释。