伴有7号染色体缺失和10号染色体倒位的绒毛淋巴细胞性脾淋巴瘤
Splenic lymphoma with villous lymphocytes showing del(7) and inv(10).
作者信息
Wong K F, Chu Y C, Hui P K
机构信息
Department of Pathology, Queen Elizabeth Hospital, Hong Kong, China.
出版信息
Cancer Genet Cytogenet. 1998 Apr 15;102(2):145-7. doi: 10.1016/s0165-4608(97)00367-1.
A 49-year-old woman presented with splenic lymphoma with villous lymphocytes (SLVL) that showed a clonal abnormality of del(7)(q22q32) in addition to inv(10)(p13q23), the latter being a previously undescribed abnormality in chronic lymphoproliferative disorders. A review of the literature on cytogenetic abnormalities of SLVL indicates that del(7q) is strongly associated with SLVL and may be important in the pathogenesis of this disorder.
一名49岁女性被诊断为伴有绒毛状淋巴细胞的脾淋巴瘤（SLVL），除了inv(10)(p13q23)外，还显示出del(7)(q22q32)的克隆异常，后者是慢性淋巴细胞增殖性疾病中一种先前未描述的异常。对SLVL细胞遗传学异常的文献综述表明，del(7q)与SLVL密切相关，可能在该疾病的发病机制中起重要作用。
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