乳腺癌细胞中的1,25-二羟基维生素D受体
1,25-dihydroxyvitamin-D-receptor in breast cancer cells.
作者信息
Eisman J A, Martin T J, MacIntyre I, Moseley J M
出版信息
Lancet. 1979;2(8156-8157):1335-6. doi: 10.1016/s0140-6736(79)92816-2.
PMID:92676
Abstract
A specific receptor for 1,25-dihydroxyvitamin D has been demonstrated in a cultured human breast cancer cell line. This is the first such demonstration in any cancer cell. It may explain the high incidence of metastatic bone destruction and hypercalcaemia in this common malignancy, and the limited success of other steroid-receptor assays in predicting the response of breast cancer to therapy.
摘要
在一种培养的人乳腺癌细胞系中已证实存在1,25 - 二羟维生素D的特异性受体。这是在任何癌细胞中首次有此类证实。这可能解释了这种常见恶性肿瘤中转移性骨破坏和高钙血症的高发生率，以及其他类固醇受体检测在预测乳腺癌对治疗反应方面成效有限的原因。
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