Castro C A
U.S. Army Medical Research Institute of Chemical Defense, Aberdeen, Maryland, USA.
Behav Neurosci. 1997 Aug;111(4):676-82. doi: 10.1037//0735-7044.111.4.676.
Nonhuman primates display both a primacy and a recency effect when trained on a 6-item serial probe recognition task. The author has previously shown that in the rhesus monkey, diazepam (3.2 mg/kg im) interferes with the memory processes that mediate the recency effect without affecting those memory processes involved in the primacy effect (C. A. Castro, 1995). This study assessed the effects of atropine sulfate (0.2, 0.3, and 0.4 mg/kg im) on the primacy and recency effects in these same monkeys. Opposite the effects of diazepam, atropine disrupted the primacy component of the serial position curve and had no measurable effect on the recency component. In addition, the 2 highest doses of atropine disrupted accuracy on the nonmatching probe trials, whereas all 3 doses of atropine resulted in increased response latencies. These reports indicate that the primacy and recency effects in the nonhuman primate can be pharmacologically dissociated.
在一项6项序列探测识别任务中接受训练时，非人类灵长类动物会表现出首因效应和近因效应。作者之前已经表明，在恒河猴中，地西泮（3.2毫克/千克，肌肉注射）会干扰介导近因效应的记忆过程，而不会影响那些参与首因效应的记忆过程（C.A. 卡斯特罗，1995年）。本研究评估了硫酸阿托品（0.2、0.3和0.4毫克/千克，肌肉注射）对这些相同猴子的首因效应和近因效应的影响。与地西泮的作用相反，阿托品破坏了序列位置曲线的首因成分，对近因成分没有可测量的影响。此外，阿托品的2个最高剂量破坏了非匹配探测试验的准确性，而所有3个剂量的阿托品都会导致反应潜伏期延长。这些报告表明，非人类灵长类动物的首因效应和近因效应在药理学上是可以分离的。
