酵母GCN4的翻译调控。关于控制起始tRNA与核糖体结合的因子的一个窗口。 - Suppr

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超能文献

Translational regulation of yeast GCN4. A window on factors that control initiator-trna binding to the ribosome.

作者信息

Hinnebusch A G

机构信息

Laboratory of Eukaryotic Gene Regulation, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA.

出版信息

J Biol Chem. 1997 Aug 29;272(35):21661-4. doi: 10.1074/jbc.272.35.21661.

DOI:10.1074/jbc.272.35.21661

PMID:9268289

Abstract

摘要

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Translational regulation of yeast GCN4. A window on factors that control initiator-trna binding to the ribosome.酵母GCN4的翻译调控。关于控制起始tRNA与核糖体结合的因子的一个窗口。

J Biol Chem. 1997 Aug 29;272(35):21661-4. doi: 10.1074/jbc.272.35.21661.

Modulation of tRNA(iMet), eIF-2, and eIF-2B expression shows that GCN4 translation is inversely coupled to the level of eIF-2.GTP.Met-tRNA(iMet) ternary complexes.对起始甲硫氨酸转运核糖核酸（tRNA<sup>(iMet)</sup>）、真核起始因子2（eIF-2）和真核起始因子2B（eIF-2B）表达的调节表明，GCN4的翻译与eIF-2·GTP·甲硫氨酰-tRNA<sup>(iMet)</sup>三元复合物的水平呈负相关。

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Regulation of translation in eukaryotic systems.真核生物系统中翻译的调控

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[Soluble factors operating translation in yeast].[酵母中调控翻译的可溶性因子]

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Promotion of met-tRNAiMet binding to ribosomes by yIF2, a bacterial IF2 homolog in yeast.酵母中的细菌IF2同源物yIF2促进甲硫氨酰-tRNAiMet与核糖体的结合。

Science. 1998 Jun 12;280(5370):1757-60. doi: 10.1126/science.280.5370.1757.

GCD10, a translational repressor of GCN4, is the RNA-binding subunit of eukaryotic translation initiation factor-3.GCD10是GCN4的一种翻译阻遏物，是真核生物翻译起始因子3的RNA结合亚基。

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