Carboni M P, Ringel R E
Division of Pediatric Cardiology, Duke University School of Medicine, Durham, NC 28206, USA.
Pediatr Cardiol. 1997 Sep-Oct;18(5):372-5. doi: 10.1007/s002469900203.
Persistent patency of the ductus arteriosus (PDA), common in premature infants, is associated with severe respiratory distress. The likelihood and significance of finding PDA in premature infants beyond the second week of life is unknown. We retrospectively analyzed all echocardiograms obtained between 1987 and 1992 on infants <35 weeks' gestational age. Of 446 echocardiograms 77 were obtained from infants >/=14 days. Of the 77 infants, 17 (22%) were found to have PDA (group 1) and the remainder did not (group 2). Forty-eight infants had been diagnosed as having PDA prior to 14 days of age. Of these infants, 16 were from group 1. Thus only 1/17 (6%) infants diagnosed as having PDA after 2 weeks did not have a history of PDA. The presence of PDA after 2 weeks did not relate to duration of oxygen therapy, ventilator therapy, or hospital stay. Furthermore, late closure of PDA in a subgroup of 11 infants did not appear to affect these parameters. It was concluded that premature infants beyond the second week of life are unlikely to have PDA if PDA had not been diagnosed during the first 14 days. Closure of PDA beyond the second week may not improve the infant's respiratory status.
动脉导管未闭（PDA）在早产儿中很常见，与严重的呼吸窘迫有关。出生后第二周以后的早产儿发现PDA的可能性及意义尚不清楚。我们回顾性分析了1987年至1992年间对孕周小于35周的婴儿进行的所有超声心动图检查。在446份超声心动图中，77份是对出生≥14天的婴儿进行的。在这77名婴儿中，17名（22%）被发现患有PDA（第1组），其余婴儿未患PDA（第2组）。48名婴儿在14日龄之前被诊断患有PDA。在这些婴儿中，16名来自第1组。因此，出生2周后被诊断患有PDA的婴儿中，只有1/17（6%）没有PDA病史。出生2周后PDA的存在与氧疗、机械通气治疗的持续时间或住院时间无关。此外，11名婴儿亚组中PDA的延迟关闭似乎并未影响这些参数。得出的结论是，如果在出生后的前14天内未诊断出PDA，出生后第二周以后的早产儿不太可能患有PDA。出生后第二周以后PDA的关闭可能不会改善婴儿的呼吸状况。
