O'Rourke D J, El-Khuffash A, Moody C, Walsh K, Molloy E J
Department of Paediatrics, National Maternity Hospital, Dublin, Ireland.
Acta Paediatr. 2008 May;97(5):574-8. doi: 10.1111/j.1651-2227.2008.00745.x.
Patent ductus arteriosus (PDA) is associated with morbidity and mortality in premature neonates.
The effect of serial echocardiography performed by a neonatologist and early targeted medical PDA treatment was evaluated and compared to historical controls. One hundred ninety-two infants <1,500 g were included and 45 infants had a PDA.
Serial echocardiography allowed significantly earlier identification and treatment of PDA versus awaiting the evolution of clinical signs. Severe intraventricular haemorrhage and ventilator days were significantly decreased in the studied cohort following the introduction of echocardiography. In addition, hospital stay was also reduced in the non-PDA group and other outcomes were unchanged.
Serial echocardiography for PDA evaluation, performed by a neonatologist trained in echo, may reduce morbidity in preterm infant.
动脉导管未闭（PDA）与早产儿的发病率和死亡率相关。
评估由新生儿科医生进行的系列超声心动图检查及早期针对性药物治疗PDA的效果，并与历史对照组进行比较。纳入192例体重<1500克的婴儿，其中45例患有PDA。
与等待临床症状出现相比，系列超声心动图检查能显著更早地识别和治疗PDA。在引入超声心动图检查后，研究队列中严重脑室内出血和机械通气天数显著减少。此外，非PDA组的住院时间也缩短了，其他结局未改变。
由接受过超声心动图培训的新生儿科医生进行系列超声心动图检查以评估PDA，可能会降低早产儿的发病率。
