孤立性髓外浆细胞瘤

Solitary extramedullary plasmacytoma.

作者信息

Mazzone A, Girola S, Mazzucchelli I, Di Maggio E M, Cusa C, Celano M

机构信息

Dipartimento di Medicina Interna e Nefrologia, Università di Pavia, IRCCS Policlinico San Matteo.

出版信息

Recenti Prog Med. 1997 Jul-Aug;88(7-8):325-7.

PMID:9270293

Abstract

A rare case of abdominal plasmacytoma is described. A computed guided biopsy of abdominal mass permitted an accurate diagnosis. Blood findings revealed an increased gamma-globulin level and serum immunoelectrophoresis revealed high IgG-kappa spike. Bone marrow biopsy resulted negative for neoplastic infiltration. Plasmacytoma is a malignant proliferation of differentiated B lymphocytes which produce immunoglobulin. In our case, microscopically, biopsy of abdominal mass revealed the presence of plasmablasts with bizarre multiforme nuclei, spindled contours and positive immunoenzymatic reaction for CD38, suggestive for plasma cell proliferation.

摘要

本文描述了一例罕见的腹部浆细胞瘤病例。通过计算机引导下对腹部肿块进行活检得以准确诊断。血液检查结果显示γ-球蛋白水平升高，血清免疫电泳显示高IgG-κ峰。骨髓活检结果显示无肿瘤浸润。浆细胞瘤是产生免疫球蛋白的分化B淋巴细胞的恶性增殖。在我们的病例中，显微镜下，腹部肿块活检显示存在具有奇异多形核、梭形轮廓且CD38免疫酶反应阳性的成浆细胞，提示浆细胞增殖。