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[脊髓硬膜外间隙形成肿块的髓外浆细胞瘤:一例报告]

[Extramedullary plasmacytoma forming a mass in the epidural space of the spinal cord: report of a case].

作者信息

Kato T, Nakagawa Y, Sawamura Y, Imamura H, Nagashima M, Higuchi A, Hige S, Suzuki T

出版信息

No Shinkei Geka. 1987 Feb;15(2):213-8.

PMID:3561687
Abstract

Plasmacytoma often forms an intramedullary mass in the vertebrae with absorption of trabecula and cortex of the bone. However, occasionally, it forms a mass in the extramedullary space of the vertebrae. The authors report such a rare case with plasmacytoma which formed a mass in the thoracic epidural space without evidence of involvement of the adjacent vertebra. On May 22, 1985, a 80-year-old man was admitted to our clinic with chief complaints of gait disturbance and hypesthesia below the umbilical level. Difficulty of walking developed approximately four months prior to admission with gradual aggravation and hypesthesia added thereafter. Neurological examinations at admission showed paraparesis with positive Babinski's and Chaddock's reflexes, hypesthesia and disturbances of vibration and position senses below the 9th thoracic nerve level. Myelography and CT scan using metrizamide indicated a presence of epidural mass at the 8th to 9th thoracic vertebrae. There was no abnormal bony change in the spine on plain X-ray and CT scan. On May 30, 1985, total removal of epidural tumor was performed by removing the laminae from the 7th to 10th vertebrae. Histological examinations including immunological stainings showed a plasmacytoma which produced monoclonal immunoglobulin of IgG-lambda type. Radiation therapy was not carried out. The serum protein fraction, immunoglobulin, immunoelectrophoresis, Bence-Jones protein and CSF immunoglobulin examined after operation, supported a histological diagnosis of plasmacytoma. Also, slight proliferation of plasma cells was noted in the bone marrow and peripheral blood.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

浆细胞瘤常于椎骨内形成髓内肿块,伴有骨小梁和骨皮质吸收。然而,偶尔它也会在椎骨的髓外间隙形成肿块。作者报告了这样一例罕见的浆细胞瘤病例,该肿瘤在胸段硬膜外间隙形成肿块,而相邻椎体无受累迹象。1985年5月22日,一名80岁男性因步态障碍和脐水平以下感觉减退为主诉入院。入院前约四个月出现行走困难,且逐渐加重,随后又出现感觉减退。入院时神经系统检查显示双下肢轻瘫,巴宾斯基征和查多克征阳性,第9胸神经水平以下感觉减退、振动觉和位置觉障碍。使用甲泛葡胺进行的脊髓造影和CT扫描显示第8至9胸椎水平存在硬膜外肿块。X线平片和CT扫描显示脊柱无异常骨质改变。1985年5月30日,通过切除第7至10胸椎的椎板对硬膜外肿瘤进行了全切除。包括免疫染色在内的组织学检查显示为浆细胞瘤,产生IgG-λ型单克隆免疫球蛋白。未进行放射治疗。术后检测的血清蛋白组分、免疫球蛋白、免疫电泳、本周蛋白和脑脊液免疫球蛋白均支持浆细胞瘤的组织学诊断。此外,骨髓和外周血中可见浆细胞轻度增生。(摘要截短至250字)

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