Serre I, Cano J P, Picot M C, Meynadier J, Meunier L
Laboratory of Drug Toxicology, University of Montpellier, France.
J Am Acad Dermatol. 1997 Aug;37(2 Pt 1):187-94. doi: 10.1016/s0190-9622(97)80123-5.
Cutaneous exposure to UVB radiation impairs the induction of contact hypersensitivity (CHS). Variable results have been found among studies examining the use of sunscreens to prevent UV-induced immunosuppression.
Our purpose was to determine whether solar-simulated exposure of human skin resulted in an impairment of CHS responses and whether the preapplication of an intermediate sun protection factor (SPF) sunscreen could prevent this locally UV-induced immunosuppression.
Irritant and CHS responses to dinitrochlorobenzene (DNCB) were randomly assessed in 160 human volunteers with or without UV exposure and with or without prior application of an SPF 15 sunscreen with high UVA protection. DNCB sensitization was performed 3 days after acute UV irradiation corresponding to 3 minimal erythema doses.
After solar-simulated UV exposure, the percentage of positive responses to DNCB sensitization dropped from 95% to 50% (p = 0.003). Prior application of the sunscreen formulation did not modify the percentage of positive responses (90%) and maintained the immunization rate at 85% among volunteers exposed to UV.
A localized sunburn can impair the afferent arm of CHS reactions in humans. The use of intermediate SPF sunscreens with high UVA protection adequately protects from the suppression of CHS responses that occurs after acute solar-simulated UV exposure.
皮肤暴露于中波紫外线辐射会损害接触性超敏反应（CHS）的诱导。在研究使用防晒霜预防紫外线诱导的免疫抑制的研究中发现了不同的结果。
我们的目的是确定模拟阳光照射人体皮肤是否会导致CHS反应受损，以及预先涂抹中等防晒系数（SPF）的防晒霜是否可以预防这种局部紫外线诱导的免疫抑制。
在160名人类志愿者中，随机评估对二硝基氯苯（DNCB）的刺激性和CHS反应，这些志愿者有或没有紫外线暴露，以及有或没有预先涂抹具有高UVA防护的SPF 15防晒霜。在相当于3个最小红斑量的急性紫外线照射3天后进行DNCB致敏。
模拟阳光紫外线照射后，对DNCB致敏的阳性反应百分比从95%降至50%（p = 0.003）。预先涂抹防晒配方并没有改变阳性反应的百分比（90%），并且在暴露于紫外线的志愿者中，免疫率维持在85%。
局部晒伤会损害人类CHS反应的传入臂。使用具有高UVA防护的中等SPF防晒霜可充分防止急性模拟阳光紫外线照射后发生的CHS反应抑制。
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