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胸腺因子(TFX)治疗慢性自身免疫性溶血性贫血的试验

[A trial of treatment with thymus factor (TFX) for chronic autoimmune hemolytic anemias].

作者信息

Słomkowski M

机构信息

Kliniki Hematologicznej Instytutu Hematologii i Transfuzjologii w Warszawie.

出版信息

Pol Merkur Lekarski. 1996 Nov;1(5):327-8.

PMID:9273208
Abstract

30 days treatment TFX was performed in 8 cases AIHA (autoimmune hemolytic anemia) with presence of warm antibodies refractory after routine treatment (glucocorticosteroids, azathioprine, splenectomy): After TFX treatment in 2 cases autoantibodies were not detectable, in 5 cases reaction DAT (direct antiglobulin test) was decreased. Eluate antibody level and serum antibody level were decreased, too. Decreasing amount of red cells autoantibodies was confirmed by enzyme-linked antiglobulin test (ELAT) in 2 cases. Autoantibody level measured by semiquantitative and quantitative methods did not increase in any other case. Adverse effects of TFX treatment were not observed.

摘要

对8例常规治疗(糖皮质激素、硫唑嘌呤、脾切除术)后难治的伴有温抗体的自身免疫性溶血性贫血(AIHA)患者进行了30天的他克莫司(TFX)治疗:TFX治疗后,2例患者的自身抗体检测不到,5例患者的直接抗球蛋白试验(DAT)反应降低。洗脱液抗体水平和血清抗体水平也降低。2例患者通过酶联抗球蛋白试验(ELAT)证实红细胞自身抗体数量减少。在其他任何病例中,通过半定量和定量方法测量的自身抗体水平均未升高。未观察到TFX治疗的不良反应。

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